Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells

Sorafenib, an orally available kinase inhibitor, is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), and it exerts potent inhibitory activity against epithelial–mesenchymal transition (EMT) and multidrug resistance (MDR) by inhibiting mitogen-activated protein kinas...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dong, Jiejie, Zhai, Bo, Sun, Weihua, Hu, Fengli, Cheng, Hao, Xu, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608310/
https://ncbi.nlm.nih.gov/pubmed/28934275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185088
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