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Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest
RATIONALE: Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial glucose oxidation, is inhibited by increased expression of PDH kinase (PDK) during ischemia/reperfusion injury. This results in decreas...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5608301/ https://ncbi.nlm.nih.gov/pubmed/28934276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185046 |
| Oznake: |
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