The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

BACKGROUND: Right ventricular hypertrophy (RVH) and RV failure contribute to morbidity and mortality in pulmonary arterial hypertension (PAH). The cause of RV dysfunction and the feasibility of therapeutically targeting the RV are uncertain. We hypothesized that RV dysfunction and electrical remodel...

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Autori principali: Piao, Lin, Fang, Yong-Hu, Cadete, Virgilio J. J., Wietholt, Christian, Urboniene, Dalia, Toth, Peter T., Marsboom, Glenn, Zhang, Hannah J., Haber, Idith, Rehman, Jalees, Lopaschuk, Gary D., Archer, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155251/
https://ncbi.nlm.nih.gov/pubmed/19949938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-009-0524-6
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