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Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

Bidirectional replication from eukaryotic DNA replication origins requires the loading of two ring-shaped Minichromosome Maintenance (MCM) helicases around DNA in opposite orientations. MCM loading is orchestrated by binding of the Origin Recognition Complex (ORC) to DNA, but how ORC coordinates sym...

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Bibliographic Details
Published in:Science
Main Authors: Coster, Gideon, Diffley, John F.X
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608077/
https://ncbi.nlm.nih.gov/pubmed/28729513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan0063
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