PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells

Hypoxia is a primary factor in many pathological conditions. Hypoxic cell death is commonly attributed to metabolic failure and oxidative injury. cAMP-dependent protein kinase A (PKA) is activated in hypoxia and regulates multiple enzymes of the mitochondrial electron transport chain, thus may be im...

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Gepubliceerd in:Toxicol Lett
Hoofdauteurs: Gozal, Evelyne, Metz, Cynthia J., Dematteis, Maurice, Sachleben, Leroy R., Schurr, Avital, Rane, Madhavi J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608019/
https://ncbi.nlm.nih.gov/pubmed/28751209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2017.07.895
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