Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17

Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. Although previous studies have demonstrated that expr...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Yang, Yang, Yang, Su, Guo, Jifeng, Cui, Yiting, Tang, Beisha, Li, Xiao-Jiang, Li, Shihua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607462/
https://ncbi.nlm.nih.gov/pubmed/28821675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0111-17.2017
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