Synthesis and preliminary studies of a novel negative allosteric modulator [(11)C]QCA for imaging of metabotropic glutamate receptor 2

Metabotropic glutamate 2 receptors (mGlu(2)) are involved in the pathogenesis of several CNS disorders and neurodegenerative diseases. Pharmacological modulation of this target represents a potential disease-modifying approach for the treatment of substance abuse, depression, schizophrenia and demen...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Zhang, Xiaofei, Kumata, Katsushi, Yamasaki, Tomoteru, Cheng, Ran, Hatori, Akiko, Ma, Longle, Zhang, Yiding, Xie, Lin, Wang, Lu, Kang, Hye Jin, Sheffler, Douglas J., Cosford, Nicholas D. P., Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607115/
https://ncbi.nlm.nih.gov/pubmed/28565908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00098
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