Ester-prodrugs of ethambutol control its antibacterial activity and provide rapid screening for mycobacterial hydrolase activity

M. tuberculosis; contains an unusually high number of serine hydrolases by proteome percentage compared to other common bacteria or humans. This letter describes a method to probe the global substrate specificity of mycobacterial serine hydrolases with ester-protected prodrugs of ethambutol, a first...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Larsen, Erik M., Stephens, Dominique C., Clarke, Nathan H., Johnson, R. Jeremy
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607105/
https://ncbi.nlm.nih.gov/pubmed/28882482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.08.057
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