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Antibody format and drug release rate determine the therapeutic activity of non-internalizing antibody-drug conjugates
The development of antibody-drug conjugates (ADCs), a promising class of anti-cancer agents, has traditionally relied on the use of antibodies capable of selective internalization in tumor cells. We have recently shown that also non-internalizing antibodies, coupled to cytotoxic drugs by means of di...
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| Publicado no: | Mol Cancer Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5606287/ https://ncbi.nlm.nih.gov/pubmed/26294742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0480 |
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