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Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy

Lot release and stability testing of biologics are essential parts of the quality control strategy for ensuring therapeutic material dosed to patients is safe and efficacious, and consistent with previous clinical and toxicological experience. Characterization of protein aggregation is of particular...

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Detalles Bibliográficos
Publicado en:Anal Chim Acta
Main Authors: Zhang, Chi, Springall, Jeremy Samuel, Wang, Xiangyang, Barman, Ishan
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750807/
https://ncbi.nlm.nih.gov/pubmed/31446951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2019.07.007
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