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Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy

Lot release and stability testing of biologics are essential parts of the quality control strategy for ensuring therapeutic material dosed to patients is safe and efficacious, and consistent with previous clinical and toxicological experience. Characterization of protein aggregation is of particular...

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Bibliografiska uppgifter
I publikationen:Anal Chim Acta
Huvudupphovsmän: Zhang, Chi, Springall, Jeremy Samuel, Wang, Xiangyang, Barman, Ishan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750807/
https://ncbi.nlm.nih.gov/pubmed/31446951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2019.07.007
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