SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-κB Inflammatory Signaling in Rat Mesangial Cells

BACKGROUND: Sumoylation is extensively involved in the regulation of NF-κB signaling. PIASy, as a SUMO E3 ligase, has been proved to mediate sumoylation of IκB kinase γ (IKKγ) and contribute to the activation of NF-κB under genotoxic agent stimulation. However, the association of PIASy and NF-κB sig...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Huang, Wei, Liang, Yaling, Dong, Jianhua, Zhou, Luping, Gao, Chenlin, Jiang, Chunxia, Chen, Meijuan, Long, Yang, Xu, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605875/
https://ncbi.nlm.nih.gov/pubmed/29038616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/1685194
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