Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. Five Hsa21 miRNA...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Genomics
Auteurs principaux: Izzo, Antonella, Manco, Rosanna, de Cristofaro, Tiziana, Bonfiglio, Ferdinando, Cicatiello, Rita, Mollo, Nunzia, Martino, Marco De, Genesio, Rita, Zannini, Mariastella, Conti, Anna, Nitsch, Lucio
Format: Artigo
Langue:Inglês
Publié: Hindawi 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605795/
https://ncbi.nlm.nih.gov/pubmed/29057256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8737649
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