Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. Five Hsa21 miRNA...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Genomics
Hauptverfasser: Izzo, Antonella, Manco, Rosanna, de Cristofaro, Tiziana, Bonfiglio, Ferdinando, Cicatiello, Rita, Mollo, Nunzia, Martino, Marco De, Genesio, Rita, Zannini, Mariastella, Conti, Anna, Nitsch, Lucio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605795/
https://ncbi.nlm.nih.gov/pubmed/29057256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8737649
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