Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis

Spatiotemporal balancing of cellular proliferation and differentiation is crucial for postnatal tissue homoeostasis and organogenesis. During embryonic development, pancreatic progenitors simultaneously proliferate and differentiate into the endocrine, ductal and acinar lineages. Using in vivo clona...

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Vydáno v:Nat Commun
Hlavní autoři: Larsen, Hjalte List, Martín-Coll, Laura, Nielsen, Alexander Valentin, Wright, Christopher V. E., Trusina, Ala, Kim, Yung Hae, Grapin-Botton, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605525/
https://ncbi.nlm.nih.gov/pubmed/28928395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00258-4
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