Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells

Conventional DNA bisulfite sequencing has been extended to single cell level, but the coverage consistency is insufficient for parallel comparison. Here we report a novel method for genome-wide CpG island (CGI) methylation sequencing for single cells (scCGI-seq), combining methylation-sensitive rest...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Han, Lin, Wu, Hua-Jun, Zhu, Haiying, Kim, Kun-Yong, Marjani, Sadie L., Riester, Markus, Euskirchen, Ghia, Zi, Xiaoyuan, Yang, Jennifer, Han, Jasper, Snyder, Michael, Park, In-Hyun, Irizarry, Rafael, Weissman, Sherman M., Michor, Franziska, Fan, Rong, Pan, Xinghua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605247/
https://ncbi.nlm.nih.gov/pubmed/28126923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx026
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