The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity

BACKGROUND: Atypical teratoid/rhabdoid tumors (AT/RTs) are deadly pediatric brain tumors driven by LIN28. Mammalian target of rapamycin (mTOR) is activated in many deadly, drug-resistant cancers and governs important cellular functions such as metabolism and survival. LIN28 regulates mTOR in normal...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Rubens, Jeffrey A, Wang, Sabrina Z, Price, Antoinette, Weingart, Melanie F, Allen, Sariah J, Orr, Brent A, Eberhart, Charles G, Raabe, Eric H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604899/
https://ncbi.nlm.nih.gov/pubmed/28582547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox067
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