RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking mitochondrial antiviral-signali...

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Publicado en:Sci Transl Med
Main Authors: Fischer, Julius C., Bscheider, Michael, Eisenkolb, Gabriel, Lin, Chia-Ching, Wintges, Alexander, Otten, Vera, Lindemans, Caroline A., Heidegger, Simon, Rudelius, Martina, Monette, Sébastien, Porosnicu Rodriguez, Kori A., Calafiore, Marco, Liebermann, Sophie, Liu, Chen, Lienenklaus, Stefan, Weiss, Siegfried, Kalinke, Ulrich, Ruland, Jürgen, Peschel, Christian, Shono, Yusuke, Docampo, Melissa, Velardi, Enrico, Jenq, Robert R., Hanash, Alan M., Dudakov, Jarrod A., Haas, Tobias, van den Brink, Marcel R. M., Poeck, Hendrik
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604790/
https://ncbi.nlm.nih.gov/pubmed/28424327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag2513
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