RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking mitochondrial antiviral-signali...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Fischer, Julius C., Bscheider, Michael, Eisenkolb, Gabriel, Lin, Chia-Ching, Wintges, Alexander, Otten, Vera, Lindemans, Caroline A., Heidegger, Simon, Rudelius, Martina, Monette, Sébastien, Porosnicu Rodriguez, Kori A., Calafiore, Marco, Liebermann, Sophie, Liu, Chen, Lienenklaus, Stefan, Weiss, Siegfried, Kalinke, Ulrich, Ruland, Jürgen, Peschel, Christian, Shono, Yusuke, Docampo, Melissa, Velardi, Enrico, Jenq, Robert R., Hanash, Alan M., Dudakov, Jarrod A., Haas, Tobias, van den Brink, Marcel R. M., Poeck, Hendrik
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604790/
https://ncbi.nlm.nih.gov/pubmed/28424327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag2513
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