Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke

BACKGROUND: Elevated plasma homocysteine (Hcy) levels have been indicated as a strong and modifiable risk factor of ischemic stroke; the previous studies have shown that exposure to Hcy activates cultured microglia. However, whether neurotoxicity of Hcy involves microglia activation following brain...

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Publicat a:J Neuroinflammation
Autors principals: Chen, Shuang, Dong, Zhiping, Cheng, Man, Zhao, Yaqian, Wang, Mengying, Sai, Na, Wang, Xuan, Liu, Huan, Huang, Guowei, Zhang, Xumei
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604224/
https://ncbi.nlm.nih.gov/pubmed/28923114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0963-x
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