Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis

BACKGROUND & AIMS: Bcl-xL, an anti-apoptotic Bcl-2 family protein, is overexpressed in 90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, Bcl-xL expression in pancreatic intraepithelial neoplasias (PanINs) and its significance in PDAC carcinogenesis remain unclear. The aim of this st...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Ikezawa, Kenji, Hikita, Hayato, Shigekawa, Minoru, Iwahashi, Kiyoshi, Eguchi, Hidetoshi, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604117/
https://ncbi.nlm.nih.gov/pubmed/28948203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2017.02.001
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