Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes

About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to major histocompatibility complex (MHC) class I. I...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Bianchi, Frans, Textor, Johannes, van den Bogaart, Geert
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604083/
https://ncbi.nlm.nih.gov/pubmed/28959259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01118
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