Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1

Notch signaling is minimally active in neuroendocrine (NE) cancer cells. While histone deacetylase inhibitors (HDACi) suppress NE cancer growth by inducing Notch, the molecular mechanism underlying this interplay has not yet been defined. NE cancer cell lines BON, H727, and MZ‐CRC‐1 were treated wit...

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Publicat a:Cancer Med
Autors principals: Jang, Samuel, Jin, Haining, Roy, Madhuchhanda, Ma, Alice L., Gong, Shaoqin, Jaskula‐Sztul, Renata, Chen, Herbert
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Cancer Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603840/
https://ncbi.nlm.nih.gov/pubmed/28776955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1151
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