Development of GLUT4-selective antagonists for multiple myeloma therapy

Cancer cells consume more glucose to fuel metabolic programs fundamental to sustaining their survival, growth and proliferation. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose transporters. GLUT4 (SLC2A4) is highly expressed in muscle and adipose tissue. Basally ret...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Wei, Changyong, Bajpai, Richa, Sharma, Horrick, Heitmeier, Monique, Jain, Atul D., Matulis, Shannon M., Nooka, Ajay K., Mishra, Rama K., Hruz, Paul W., Schiltz, Gary E., Shanmugam, Mala
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603412/
https://ncbi.nlm.nih.gov/pubmed/28837922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.08.029
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