Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax

Multiple myeloma (MM) is a plasma cell malignancy that is largely incurable due to development of resistance to therapy-elicited cell death. Nutrients are intricately connected to maintenance of cellular viability in part by inhibition of apoptosis. We were interested to determine if examination of...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncogene
Asıl Yazarlar: Bajpai, R, Matulis, SM, Wei, C, Nooka, AK, Von Hollen, HE, Lonial, S, Boise, LH, Shanmugam, M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025767/
https://ncbi.nlm.nih.gov/pubmed/26640142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.464
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