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O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein

The major protein associated with Parkinson’s disease (PD) is α-synuclein, as it can form toxic amyloid-aggregates that are a hallmark of many neurodegenerative diseases. α-Synuclein is a substrate for several different posttranslational modifications (PTMs) that have the potential to affect its bio...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem
Asıl Yazarlar: Levine, Paul M., De Leon, Cesar A., Galesic, Ana, Balana, Aaron, Marotta, Nicholas P., Lewis, Yuka E., Pratt, Matthew R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603368/
https://ncbi.nlm.nih.gov/pubmed/28487126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.04.038
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