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O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein
The major protein associated with Parkinson’s disease (PD) is α-synuclein, as it can form toxic amyloid-aggregates that are a hallmark of many neurodegenerative diseases. α-Synuclein is a substrate for several different posttranslational modifications (PTMs) that have the potential to affect its bio...
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| Publicado en: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5603368/ https://ncbi.nlm.nih.gov/pubmed/28487126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.04.038 |
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