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Pluripotency circuit members mediate germ layer fate choice of embryonic stem cells

Cell fate decisions are fundamental for development, but we do not know how cells select between alternate fates. Here, we asked how mouse embryonic stem (ES) cells leave the pluripotent state and choose between germ layer fates. By analyzing the dynamics of the transcriptional circuit that maintain...

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Publicado en:Cell
Main Authors: Thomson, Matt, Liu, Siyuan John, Zou, Ling-Nan, Smith, Zack, Meissner, Alexander, Ramanathan, Sharad
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603300/
https://ncbi.nlm.nih.gov/pubmed/21663792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.05.017
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