The Direction of Protein Entry into the Proteasome Determines the Variety of Peptide Products and Depends on the Force Needed to Unfold Its Two Termini

Poorly structured domains in proteins enhance their susceptibility to proteasomal degradation. To learn whether the presence of such a domain near either end of a protein determines its direction of entry into the proteasome, directional translocation was enforced on several proteasome substrates. U...

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Publicado no:Mol Cell
Main Authors: Berko, Dikla, Tabachnick, Shira, Shental-Bechor, Dalit, Cascio, Paolo, Mioletti, Silvia, Levy, Yaakov, Admon, Arie, Ziv, Tamar, Tirosh, Boaz, Goldberg, Alfred L., Navon, Ami
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603081/
https://ncbi.nlm.nih.gov/pubmed/23041283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.029
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