The amyloid precursor protein modulates α(2A)-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment

The amyloid precursor protein (APP) has long been appreciated for its role in Alzheimer’s disease (AD) pathology. However, less is known about the physiologic function of APP outside of AD. Particularly, whether and how APP may regulate functions of cell surface receptors, including GPCRs, remains l...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Zhang, Fang, Gannon, Mary, Chen, Yunjia, Zhou, Lufang, Jiao, Kai, Wang, Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602903/
https://ncbi.nlm.nih.gov/pubmed/28646018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700346R
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