The amyloid precursor protein modulates α(2A)-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment

The amyloid precursor protein (APP) has long been appreciated for its role in Alzheimer’s disease (AD) pathology. However, less is known about the physiologic function of APP outside of AD. Particularly, whether and how APP may regulate functions of cell surface receptors, including GPCRs, remains l...

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Detalles Bibliográficos
Publicado en:FASEB J
Main Authors: Zhang, Fang, Gannon, Mary, Chen, Yunjia, Zhou, Lufang, Jiao, Kai, Wang, Qin
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602903/
https://ncbi.nlm.nih.gov/pubmed/28646018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700346R
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