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Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells
Tumor blood vessels support tumor growth and progression. Centrosomes are microtubule organization centers in cells, and often up to 30% of tumor endothelial cells (ECs) acquire excess (>2) centrosomes. Although excess centrosomes can lead to aneuploidy and chromosome instability in tumor cells,...
Uloženo v:
| Vydáno v: | FASEB J |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Federation of American Societies for Experimental Biology
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5602900/ https://ncbi.nlm.nih.gov/pubmed/28626028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601320R |
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