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The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

To maintain optimal fitness, a cell must balance the risk of inadequate energy reserve for response to a potentially fatal perturbation against the long-term cost of maintaining high concentrations of ATP to meet occasional spikes in demand. Here we apply a game theoretic approach to address the dyn...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Epstein, Tamir, Gatenby, Robert A., Brown, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602667/
https://ncbi.nlm.nih.gov/pubmed/28922380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185085
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