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Adaptation to stochastic temporal variations in intratumoral blood flow: the Warburg effect as a bet-hedging strategy

Vascular networks in cancers usually fail to develop a mature organization, resulting in chaotic dynamics with stochastic variations that include slowing, cessation, and even reversal of flow and will result in substantial spatial and temporal heterogeneity in oxygen concentration. Here, we consider...

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Detalhes bibliográficos
Publicado no:Bull Math Biol
Main Authors: Gravenmier, Curtis A., Siddique, Miriam, Gatenby, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685950/
https://ncbi.nlm.nih.gov/pubmed/28508297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11538-017-0261-x
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