Small-molecule CB002 restores p53 pathway signaling and represses colorectal cancer cell growth

Much effort is currently focused on the p53 pathway. p53 is a key tumor suppressor, which is mutated or lost in many human cancers. Restoration of the p53 pathway holds the potential to induce selective cell death in tumor cells without harming normal cells that have intact p53 pathways. Most tumor...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Richardson, Colby, Zhang, Shengliang, Hernandez Borrero, Liz J., El-Deiry, Wafik S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602428/
https://ncbi.nlm.nih.gov/pubmed/28749206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1356514
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