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Small-molecule CB002 restores p53 pathway signaling and represses colorectal cancer cell growth

Much effort is currently focused on the p53 pathway. p53 is a key tumor suppressor, which is mutated or lost in many human cancers. Restoration of the p53 pathway holds the potential to induce selective cell death in tumor cells without harming normal cells that have intact p53 pathways. Most tumor...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Richardson, Colby, Zhang, Shengliang, Hernandez Borrero, Liz J., El-Deiry, Wafik S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602428/
https://ncbi.nlm.nih.gov/pubmed/28749206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1356514
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