Transcription factor clusters regulate genes in eukaryotic cells

Transcription is regulated through binding factors to gene promoters to activate or repress expression, however, the mechanisms by which factors find targets remain unclear. Using single-molecule fluorescence microscopy, we determined in vivo stoichiometry and spatiotemporal dynamics of a GFP tagged...

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Udgivet i:eLife
Main Authors: Wollman, Adam JM, Shashkova, Sviatlana, Hedlund, Erik G, Friemann, Rosmarie, Hohmann, Stefan, Leake, Mark C
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Chromosomes and Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602325/
https://ncbi.nlm.nih.gov/pubmed/28841133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27451
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