Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity

BAFF is a B cell survival and maturation factor implicated in the pathogenesis of systemic lupus erythematosus (SLE). In this in vitro study, we describe that soluble BAFF in combination with IL-2 and IL-21 is a T cell contact-independent inducer of human B cell proliferation, plasmablast differenti...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Nakayama, Yumi, Kosek, Jolanta, Capone, Lori, Hur, Eun Mi, Schafer, Peter H., Ringheim, Garth E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2017
Schlagworte:
Immune Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602157/
https://ncbi.nlm.nih.gov/pubmed/28848067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601725
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