Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma

The role of the positive RNA Pol II regulator, P-TEFb (positive transcription elongation factor b), in maintenance of the anti-apoptotic protein Mcl-1 and bortezomib (btz) resistance was investigated in human multiple myeloma (MM) cells. Mcl-1 was up-regulated in all MM lines tested, including borte...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Zhang, Yu, Zhou, Liang, Leng, Yun, Dai, Yun, Orlowski, Robert Z., Grant, Steven
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601747/
https://ncbi.nlm.nih.gov/pubmed/28938651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19761
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