Prolonged Particulate Hexavalent Chromium Exposure Suppresses Homologous Recombination Repair in Human Lung Cells

Genomic instability is one of the primary models of carcinogenesis and a feature of almost all cancers. Homologous recombination (HR) repair protects against genomic instability by maintaining high genomic fidelity during the repair of DNA double strand breaks. The defining step of HR repair is the...

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Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Browning, Cynthia L., Qin, Qin, Kelly, Deborah F., Prakash, Rohit, Vanoli, Fabio, Jasin, Maria, Wise, John Pierce
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Hexavalent Chromium Exposure and DNA Repair in Lung Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601504/
https://ncbi.nlm.nih.gov/pubmed/27449664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw103
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