Homologous Recombination Repair Signaling in Chemical Carcinogenesis: Prolonged Particulate Hexavalent Chromium Exposure Suppresses the Rad51 Response in Human Lung Cells

The aim of this study was to focus on hexavalent chromium, [Cr(VI)], a chemical carcinogen and major public health concern, and consider its ability to impact DNA double strand break repair. We further focused on particulate Cr(VI), because it is the more potent carcinogenic form of Cr(VI). DNA doub...

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Опубликовано в: :Toxicol Sci
Главные авторы: Qin, Qin, Xie, Hong, Wise, Sandra S., Browning, Cynthia L., Thompson, Kelsey N., Holmes, Amie L., Wise, John Pierce
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271064/
https://ncbi.nlm.nih.gov/pubmed/25173789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu175
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