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Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis

The alanine:glyoxylate aminotransferase (AGT), a hepatocyte-specific pyridoxal-5′-phosphate (PLP) dependent enzyme, transaminates L-alanine and glyoxylate to glycine and pyruvate, thus detoxifying glyoxylate and preventing pathological oxalate precipitation in tissues. In the widely accepted catalyt...

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Publicat a:Sci Rep
Autors principals: Giardina, Giorgio, Paiardini, Alessandro, Montioli, Riccardo, Cellini, Barbara, Voltattorni, Carla Borri, Cutruzzolà, Francesca
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601474/
https://ncbi.nlm.nih.gov/pubmed/28916765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11948-w
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