Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Mitochondrial health is critical for skeletal muscle function and is improved by exercise training through both mitochondrial biogenesis and removal of damaged/dysfunctional mitochondria via mitophagy. The mechanisms underlying exercise-induced mitophagy have not been fully elucidated. Here, we show...

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Pubblicato in:Nat Commun
Autori principali: Laker, Rhianna C., Drake, Joshua C., Wilson, Rebecca J., Lira, Vitor A., Lewellen, Bevan M., Ryall, Karen A., Fisher, Carleigh C., Zhang, Mei, Saucerman, Jeffrey J., Goodyear, Laurie J., Kundu, Mondira, Yan, Zhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601463/
https://ncbi.nlm.nih.gov/pubmed/28916822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00520-9
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