Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Mitochondrial health is critical for skeletal muscle function and is improved by exercise training through both mitochondrial biogenesis and removal of damaged/dysfunctional mitochondria via mitophagy. The mechanisms underlying exercise-induced mitophagy have not been fully elucidated. Here, we show...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Laker, Rhianna C., Drake, Joshua C., Wilson, Rebecca J., Lira, Vitor A., Lewellen, Bevan M., Ryall, Karen A., Fisher, Carleigh C., Zhang, Mei, Saucerman, Jeffrey J., Goodyear, Laurie J., Kundu, Mondira, Yan, Zhen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601463/
https://ncbi.nlm.nih.gov/pubmed/28916822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00520-9
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