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Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Tyrosinase‐related protein 1 (TYRP1) is one of three tyrosinase‐like glycoenzymes in human melanocytes that are key to the production of melanin, the compound responsible for the pigmentation of skin, eye, and hair. Difficulties with producing these enzymes in pure form have hampered the understandi...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Lai, Xuelei, Wichers, Harry J., Soler‐Lopez, Montserrat, Dijkstra, Bauke W.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601231/
https://ncbi.nlm.nih.gov/pubmed/28661582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201704616
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