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Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Tyrosinase‐related protein 1 (TYRP1) is one of three tyrosinase‐like glycoenzymes in human melanocytes that are key to the production of melanin, the compound responsible for the pigmentation of skin, eye, and hair. Difficulties with producing these enzymes in pure form have hampered the understandi...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Lai, Xuelei, Wichers, Harry J., Soler‐Lopez, Montserrat, Dijkstra, Bauke W.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601231/
https://ncbi.nlm.nih.gov/pubmed/28661582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201704616
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