Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma

The endosialin/CD248/TEM1 receptor is expressed on the cell surface of tumor-associated stroma cells as well as in sarcoma and neuroblastoma cells. This receptor is emerging as an attractive molecule in diagnostics and therapeutics because of its expression across the stroma of many human tumors, th...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Capone, Emily, Piccolo, Enza, Fichera, Imma, Ciufici, Paolo, Barcaroli, Daniela, Sala, Arturo, De Laurenzi, Vincenzo, Iacobelli, Valentina, Iacobelli, Stefano, Sala, Gianluca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601145/
https://ncbi.nlm.nih.gov/pubmed/28947977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19499
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