Genetic Epistasis Regulates Amyloid Deposition in Resilient Aging

INTRODUCTION: The brain-derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer’s disease (AD) risk factors. Specifically, variants within the SORL1 gene determine BDNF’s ability to reduce Aβ in vitro. We sought to test whether functional BDNF variation interacts with SORL1 gen...

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Bibliografiske detaljer
Udgivet i:Alzheimers Dement
Main Authors: Felsky, Daniel, Xu, Jishu, Chibnik, Lori, Schneider, Julie, Knight, Jo, Kennedy, James L, Bennett, David A, De Jager, Philip L, Voineskos, Aristotle N
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601013/
https://ncbi.nlm.nih.gov/pubmed/28322202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2017.01.027
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