Androgen Receptor Variants Mediate DNA Repair Following Radiation in Prostate Cancer

Recently, the combination of androgen deprivation therapy (ADT) and radiation therapy (RT) has been shown to block the androgen receptor (AR)-driven DNA damage response (DDR) and enhance RT-mediated cell kill of prostate cancer (PCa). Since ADT may induce expression of AR splice variants (ARVs) we h...

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Udgivet i:Cancer Res
Main Authors: Yin, Yi, Li, Rui, Xu, Kangling, Ding, Sentai, Li, Jeffrey, Baek, GuemHee, Ramanand, Susmita G., Ding, Sam, Liu, Zhao, Gao, Yunpeng, Kanchwala, Mohammed, Li, Xiangyi, Hutchinson, Ryan, Liu, Xihui, Woldu, Solomon, Xing, Chao, Desai, Neil B., Feng, Felix Y., Burma, Sandeep, de Bono, Johann, Dehm, Scott M., Mani, Ram S., Chen, Benjamin P.C., Raj, Ganesh V.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600864/
https://ncbi.nlm.nih.gov/pubmed/28754673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0164
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