Antibodies to α5 chain of collagen IV are pathogenic in Goodpasture disease

Autoantibody against glomerular basement membrane (GBM) plays a direct role in the initiation and development of Goodpasture’s (GP) disease. The principal autoantigen is the non-collagenous domain 1 (NC1) of α3 chain of collagen IV, with two immunodominant epitopes, E(A)-α3 and E(B)-α3. We recently...

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Udgivet i:J Autoimmun
Main Authors: Cui, Zhao, Zhao, Ming-hui, Jia, Xiao-yu, Wang, Miao, Hu, Shui-yi, Wang, Su-xia, Yu, Feng, Brown, Kyle L, Hudson, Billy G, Pedchenko, Vadim
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600521/
https://ncbi.nlm.nih.gov/pubmed/27117167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.04.001
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