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Goodpasture’s Disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis

PURPOSE OF REVIEW: Goodpasture’s (GP) disease is an autoimmune disorder characterized by the deposition of pathogenic autoantibodies in basement membranes of kidney and lung, which induces rapidly progressive glomerulonephritis and pulmonary hemorrhage. The target antigen is the α3NC1 domain of coll...

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Main Authors: Pedchenko, Vadim, Vanacore, Roberto, Hudson, Billy
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159420/
https://ncbi.nlm.nih.gov/pubmed/21378566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MNH.0b013e328344ff20
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