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Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies

Multiple treatment strategies are available for empiric antibiotic therapy in hospitals, but neither clinical studies nor theoretical investigations have yielded a clear picture when which strategy is optimal and why. Extending earlier work of others and us, we present a mathematical model capturing...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Autores principales: Tepekule, Burcu, Uecker, Hildegard, Derungs, Isabel, Frenoy, Antoine, Bonhoeffer, Sebastian
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600366/
https://ncbi.nlm.nih.gov/pubmed/28915236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005745
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