A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca(2+) transients and prevents cardiac cell death through restoration of mitochondrial function

A key contributor to the pathophysiology of diabetic cardiomyopathy, mitochondrial superoxide can be adequately countered by Mn-superoxide dismutase, which constitutes the first line of defense against mitochondrial oxidative stress. Our group has recently synthesized low molecular weight SOD mimics...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Kain, Vasundhara, Sawant, Mithila A., Dasgupta, Aparajita, Jaiswal, Gaurav, Vyas, Alok, Padhye, Subhash, Sitasawad, Sandhya L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600348/
https://ncbi.nlm.nih.gov/pubmed/28955837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.01.003
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